{"id":9306,"date":"2021-06-18T08:59:09","date_gmt":"2021-06-18T13:59:09","guid":{"rendered":"http:\/\/losperiodistas.com.mx\/portal\/?p=9306"},"modified":"2021-06-18T08:59:10","modified_gmt":"2021-06-18T13:59:10","slug":"identifican-las-moleculas-que-frenan-la-entrada-del-sars-cov-2-en-las-celulas-la-razon","status":"publish","type":"post","link":"https:\/\/losperiodistas.com.mx\/portal\/identifican-las-moleculas-que-frenan-la-entrada-del-sars-cov-2-en-las-celulas-la-razon\/","title":{"rendered":"Identifican las mol\u00e9culas que frenan la entrada del SARS-CoV-2 en las c\u00e9lulas | La Raz\u00f3n"},"content":{"rendered":"\n<p style=\"font-size:18px\"><em>Estos compuestos inhiben la interacci\u00f3n de la prote\u00edna spike del virus con los receptores celulares y bloquean la entrada del SARS-CoV-2 en la c\u00e9lula, por lo que \u201cse podr\u00eda valorar su uso como tratamiento preventivo de la infecci\u00f3n\u201d<\/em><\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"651\" src=\"https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2021\/06\/Captura-de-Pantalla-2021-06-18-a-las-8.55.55-1024x651.jpg\" alt=\"\" class=\"wp-image-9307\" srcset=\"https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2021\/06\/Captura-de-Pantalla-2021-06-18-a-las-8.55.55-1024x651.jpg 1024w, https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2021\/06\/Captura-de-Pantalla-2021-06-18-a-las-8.55.55-300x191.jpg 300w, https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2021\/06\/Captura-de-Pantalla-2021-06-18-a-las-8.55.55-768x488.jpg 768w, https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2021\/06\/Captura-de-Pantalla-2021-06-18-a-las-8.55.55.jpg 1198w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption><strong>Recreaci\u00f3n art\u00edstica del virus SARS-CoV-2<\/strong> PIXABAY<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-medium-font-size\">BEL\u00c9N TOBALINA \/ LA RAZ\u00d3N<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Un proyecto desarrollado por investigadores del Consejo Superior de Investigaciones Cient\u00edficas (CSIC) ha identificado distintos compuestos moleculares que impiden la entrada del SARS-CoV-2 en las c\u00e9lulas, al inhibir la interacci\u00f3n que se produce entre la prote\u00edna de la esp\u00edcula del virus y los receptores celulares.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Noticias relacionadas<\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.larazon.es\/salud\/20210618\/7evobf5ywjalhk74jekycvoeze.html\">Investigaci\u00f3n.&nbsp;Descubren una nueva v\u00eda para hacer frente a la infecci\u00f3n por Covid-19 que logra reducir en un 99,5% su propagaci\u00f3n<\/a><\/li><\/ul>\n\n\n\n<p><strong>Estas mol\u00e9culas act\u00faan en etapas muy tempranas del ciclo replicativo viral, por lo que podr\u00edan impedir la hiperactivaci\u00f3n del sistema inmunol\u00f3gico que desencadena la&nbsp;<\/strong><em><strong>tormenta de citoquinas<\/strong><\/em><strong>&nbsp;durante el agravamiento de la Covid-19<\/strong>. Estos compuestos podr\u00edan servir para desarrollar f\u00e1rmacos antivirales contra el SARS-CoV-2.<\/p>\n\n\n\n<p>Los compuestos identificados como inhibidores de entrada del virus son mol\u00e9culas propias del grupo liderado por Mar\u00eda Jes\u00fas P\u00e9rez P\u00e9rez, investigadora del CSIC en el Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC).&nbsp;<strong>\u201cEmpleando el s\u00edmil de la puerta, persiguen bloquear la puerta principal por la que el virus accede al interior celular. De este modo, proteger\u00edan a las c\u00e9lulas de la infecci\u00f3n viral<\/strong>\u201d, explicaP\u00e9rez, que lidera el proyecto junto con Sonsoles Mart\u00ednSantamar\u00eda, del Centro de Investigaciones Biol\u00f3gicas Margarita Salas (CIB-CSIC), Ron Geller, del Instituto de Biolog\u00eda Integrativa y de Sistemas, centro mixto del CSIC y la Universidad de Valencia (I2SysBio-CSIC-UV) y Alberto Marina y Vicente Rubio<strong>,<\/strong>&nbsp;ambos del Instituto de Biomedicina de Valencia (IBV-CSIC).<\/p>\n\n\n\n<p>Los investigadores ensayaron los f\u00e1rmacos usando pseudopart\u00edculas virales con la prote\u00edna de la esp\u00edcula del virus SARS-CoV-2 expresada en su superficie. A continuaci\u00f3n, se analiz\u00f3 su capacidad para interferir entre la uni\u00f3n de la prote\u00edna de la esp\u00edcula con el receptor celular y la posterior infecci\u00f3n.<\/p>\n\n\n\n<p>\u201cHemos logrado la inhibici\u00f3n de la entrada del virus a concentraciones bajas sin que se genere toxicidad en las c\u00e9lulas hu\u00e9sped. Esto genera un amplio \u00edndice de selectividad, un par\u00e1metro que mide la diferencia en concentraciones entre la actividad antiviral y la toxicidad frente a c\u00e9lulas no infectadas. Se trata de un factor importante a la hora de desarrollar f\u00e1rmacos antivirales\u201d, se\u00f1ala la investigadora del CSIC.<\/p>\n\n\n\n<p>Los compuestos identificados act\u00faan en etapas muy tempranas del ciclo replicativo viral. Al impedir la replicaci\u00f3n del virus en la c\u00e9lula, podr\u00edan evitar los efectos de la tormenta de citoquinas. \u201c<strong>Incluso se podr\u00eda valorar su uso como tratamiento preventivo de la infecci\u00f3n.\u00a0<\/strong>A partir de ahora, se inicia un largo camino que incluye su estudio precl\u00ednico y su evaluaci\u00f3n de eficacia en un modelo animal\u201d, concluye P\u00e9rez.<\/p>\n\n\n\n<p>Fuente: https:\/\/www.larazon.es\/salud\/20210618\/4znqofeuhvhgxkgppk3ym5anhm.html<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estos compuestos inhiben la interacci\u00f3n de la prote\u00edna spike del virus con los receptores celulares y bloquean la entrada del 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