KATE KELLAND\/ INFOBAE<\/p>\n\n\n\n
LONDRES, 11 dic (Reuters) – Cinco genes clave est\u00e1n asociados con los casos m\u00e1s severos de COVID-19, dijeron el viernes cient\u00edficos, en una investigaci\u00f3n que tambi\u00e9n apunt\u00f3 a varios medicamentos existentes que podr\u00edan ser utilizados para tratar a la gente con riesgo de enfermar de gravedad por la pandemia.<\/p>\n\n\n\n
Los investigadores que estudiaron el ADN de 2.700 pacientes de COVID-19 en 208 unidades de cuidados intensivos en Reino Unido hallaron que cinco genes involucrados en dos procesos moleculares -inmunidad antiviral e inflaci\u00f3n pulmonar- son clave en muchos casos severos.<\/p>\n\n\n\n
\u00abNuestros resultados destacan inmediatamente qu\u00e9 medicamentos deber\u00edan estar en lo m\u00e1s alto de la lista para ensayos cl\u00ednicos\u00bb, dijo Kenneth Baillie, consultor acad\u00e9mico de medicina de cuidado cr\u00edtico en la Universidad de Edimburgo, uno de los coautores del estudio.<\/p>\n\n\n\n
Los genes, llamados IFNAR2, TYK2, OAS1, DPP9 y CCR2, explican parcialmente por qu\u00e9 algunas personas sufren casos m\u00e1s graves de COVID-19, mientras que otros no son afectados, dijo Baillie.<\/p>\n\n\n\n
Los hallazgos, publicados en la revista Nature, deber\u00edan ayudar a los cient\u00edficos a acelerar la investigaci\u00f3n de medicamentos potenciales para el COVID-19 al realizar ensayos cl\u00ednicos de medicinas que se concentran en v\u00edas antivirales y antinflamatorias espec\u00edficas.<\/p>\n\n\n\n
Entre aquellos con mayor potencial, dijo, deber\u00eda estar una clase de medicamentos antinflamatorio llamado inhibidores JAK, que incluyen la medicina para la artritis baricitinib, producida por Eli Lilly.<\/p>\n\n\n\n
El equipo de Baillie tambi\u00e9n hall\u00f3 que un aumento de la actividad del gen INFAR2 podr\u00eda crear protecci\u00f3n contra el COVID-19, porque es posible que se asemeje al tratamiento con interfer\u00f3n.<\/p>\n\n\n\n
Varios medicamentos existentes est\u00e1n siendo explorados en ensayos cl\u00ednicos para su potencial uso contra el COVID-19, incluido interfer\u00f3n-beta-1a, antagonista del receptor interleucina-1 y Kevzara, la medicina de Sanofi para la artritis.<\/p>\n\n\n\n
Hasta ahora, el esteroide llamado dexametasona y un antiviral recientemente desarrollado llamado remdesivir, producido por Gilead, son los \u00fanicos medicamentos autorizados en el mundo para tratar a los pacientes de COVID-19 -aunque remdesivir no es recomendado para los casos graves de la enfermedad y ha tenido resultados dispares en los ensayos.<\/p>\n\n\n\n
El mes pasado, la Administraci\u00f3n de Medicamentos y Alimentos aprob\u00f3 el anticuerpo de Eli Lilly bamlanivimab para pacientes de COVID-19 que no est\u00e1n hospitalizados pero corren riesgo de un cuadro grave debido a su edad u otras condiciones. (Reporte de Kate Kelland, Editado en Espa\u00f1ol por Ricardo Figueroa)<\/p>\n\n\n\n
Fuente: https:\/\/www.infobae.com\/america\/agencias\/2020\/12\/11\/hallan-cinco-genes-clave-en-pacientes-con-covid-19-severo-recomiendan-estudios-de-medicamentos\/<\/p>\n","protected":false},"excerpt":{"rendered":"
KATE KELLAND\/ INFOBAE LONDRES, 11 dic (Reuters) – Cinco genes clave est\u00e1n asociados con los casos m\u00e1s severos de COVID-19, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2261","post","type-post","status-publish","format-standard","hentry","category-noticias"],"_links":{"self":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/2261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/comments?post=2261"}],"version-history":[{"count":1,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/2261\/revisions"}],"predecessor-version":[{"id":2262,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/2261\/revisions\/2262"}],"wp:attachment":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/media?parent=2261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/categories?post=2261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/tags?post=2261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}