{"id":21628,"date":"2022-02-16T08:50:57","date_gmt":"2022-02-16T14:50:57","guid":{"rendered":"http:\/\/losperiodistas.com.mx\/portal\/?p=21628"},"modified":"2022-02-16T08:50:59","modified_gmt":"2022-02-16T14:50:59","slug":"remdesivir-mantiene-la-actividad-antiviral-frente-a-omicron-la-razon","status":"publish","type":"post","link":"https:\/\/losperiodistas.com.mx\/portal\/remdesivir-mantiene-la-actividad-antiviral-frente-a-omicron-la-razon\/","title":{"rendered":"Remdesivir mantiene la actividad antiviral frente a \u00d3micron | La Raz\u00f3n"},"content":{"rendered":"\n<p style=\"font-size:18px\"><em>Datos in vitro demuestran la actividad de este medicamento contra diez variantes del SARS-CoV-2<\/em><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2022\/02\/B2NBZVUMVVCAFJ5C2UYABOGAJM.jpeg\" alt=\"\" class=\"wp-image-21629\" srcset=\"https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2022\/02\/B2NBZVUMVVCAFJ5C2UYABOGAJM.jpeg 600w, https:\/\/losperiodistas.com.mx\/portal\/wp-content\/uploads\/2022\/02\/B2NBZVUMVVCAFJ5C2UYABOGAJM-300x200.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption><strong>Los datos demuestran la actividad in vitro de remdesivir contra diez variantes del SARS-CoV-2<\/strong>\u00a0<br>FOTO:\u00a0ZSOLT CZEGLEDI\u00a0AP<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-medium-font-size\">EVA S. CORADA \/ LA RAZ\u00d3N<\/p>\n\n\n\n<p>Gilead, el laboratorio que fabrica remdesivir ha publicado datos que&nbsp;<strong>demuestran su actividad in vitro de contra diez variantes del SARS-CoV-2<\/strong>, incluida \u00d3micron. Estos resultados coinciden con otros estudios in vitro realizados de forma independiente por investigadores de instituciones de otros pa\u00edses, como B\u00e9lgica, Rep\u00fablica Checa, Alemania, Polonia y Estados Unidos, que confirmaron contra variantes del SARS-CoV-2 previamente identificadas, entre ellas Alfa, Beta, Gamma, Delta y \u00d3micron.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Noticias relacionadas<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.larazon.es\/salud\/20220116\/w2ws4yt4lnf3xnhgybqktu3tea.html\">Covid-19.&nbsp;\u00d3micron limita la eficacia de los nuevos f\u00e1rmacos<\/a><\/li><li><a href=\"https:\/\/www.larazon.es\/salud\/20220110\/2bo33mlxmvdihlvpdhpu45cjii.html\">Coronavirus.&nbsp;Pfizer anuncia que tendr\u00e1 una nueva vacuna contra \u00d3micron en marzo<\/a><\/li><\/ul>\n\n\n\n<p>El estudio, que se han presentado para su publicaci\u00f3n en una revista revisada por pares y como\u00a0<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.02.09.479840v1\" target=\"_blank\" rel=\"noreferrer noopener\">pre-print en BioRxi<\/a>, analiza la actividad antiviral in vitro mediante dos m\u00e9todos para comprender la susceptibilidad de diez variantes principales del SARS-CoV-2 al f\u00e1rmaco. Los resultados del estudio mostraron una actividad similar de la terapia contra las variantes y un aislado del linaje A ancestral temprano detectado en Seattle, WA (cepa WA1). En concreto,<strong>\u00a0las variantes Delta y \u00d3micron siguieron siendo totalmente susceptibles al antiviral,<\/strong>\u00a0y estos resultados de laboratorio demuestran que ha seguido siendo activo contra todas las variantes principales aisladas en los \u00faltimos dos a\u00f1os.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Tambi\u00e9n frente a la subvariante BA.2<\/h4>\n\n\n\n<p>El antiviral inhibe directamente la replicaci\u00f3n del virus dentro de las c\u00e9lulas del hu\u00e9sped al dirigirse a la ARN polimerasa dependiente del ARN del coronavirus. Al entrar en el organismo, el f\u00e1rmaco se transforma en el metabolito trifosfato activo, que se incorpora al ARN viral y detiene la replicaci\u00f3n del virus dentro de las c\u00e9lulas infectadas.&nbsp;<strong>El estudio analiz\u00f3 casi seis millones de secuencias de variantes aisladas disponibles p\u00fablicamente<\/strong>&nbsp;y confirm\u00f3 que la prote\u00edna nsp12, la diana de la ARN polimerasa del antiviral, est\u00e1 bien conservada para todas las variantes. Una caracterizaci\u00f3n m\u00e1s detallada confirm\u00f3 que ninguna de las pocas mutaciones identificadas de nsp12 que prevalecen en algunas de las variantes del SARS-CoV-2 afecta a la susceptibilidad del virus al tratamiento.<\/p>\n\n\n\n<p>\u201cEstos resultados aportan pruebas de la\u00a0<strong>actividad antiviral consistente y duradera<\/strong>\u00a0de remdesivir en todas las variantes conocidas que han surgido a lo largo de la pandemia, incluida \u00d3micron, y apoyan su uso continuado para el tratamiento de Covid-19 para las variantes actuales de SARS-CoV-2\u2033, ha declarado Tomas Cihlar, vicepresidente senior de Investigaci\u00f3n Virol\u00f3gica de Gilead Sciences. \u201cAhora que una nueva versi\u00f3n de \u00d3micron (subvariante BA.2) est\u00e1 aumentando su circulaci\u00f3n en todo el mundo,\u00a0<strong>estos \u00faltimos datos tambi\u00e9n sugieren que remdesivir conservar\u00e1 la actividad antiviral contra esta nueva subvariante\u00a0<\/strong>porque la ARN polimerasa viral a la que se dirige no contiene ninguna mutaci\u00f3n \u00fanica adicional. Gilead eval\u00faa continuamente la actividad del antiviral contra las variantes virales\u201d.<\/p>\n\n\n\n<p>Fuente: https:\/\/www.larazon.es\/salud\/20220215\/d6fbazsizzallep4sqhea4xgje.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Datos in vitro demuestran la actividad de este medicamento contra diez variantes del SARS-CoV-2 EVA S. CORADA \/ LA RAZ\u00d3N [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21629,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8],"tags":[5593,895,6963],"class_list":["post-21628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-omicron","tag-remdesivir","tag-sars-cov-2-2"],"_links":{"self":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/21628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/comments?post=21628"}],"version-history":[{"count":1,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/21628\/revisions"}],"predecessor-version":[{"id":21630,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/posts\/21628\/revisions\/21630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/media\/21629"}],"wp:attachment":[{"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/media?parent=21628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/categories?post=21628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/losperiodistas.com.mx\/portal\/wp-json\/wp\/v2\/tags?post=21628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}